Objectives: To report the outcomes of fluocinolone acetonide intravitreal implant (FAc, Iluvien®, SIFI, Italy) in patients affected by chronic non-infectious uveitis of the posterior segment (NIU-PS).
Introduction: Macular edema in patients with posterior non-infectious uveitis (NIU-PS) may lead to irreversible visual loss if undertreated. Fluocinolone acetonide (FAc) intravitreal implant is effective in sustained control of macular edema in NIU-PS. We report the outcomes of FAc implant in patients affected by chronic NIU-PS, quantifying the functional and morphologic response in terms of area-under-the-curve (AUC); furthermore, we provide the analysis of the clinical factors associated with the AUC up to 2 years.
Materials / method: Retrospective study of patients with NIU-PS undergoing FAc implant at San Raffaele Hospital (Milan, Italy). Clinical data, including best-corrected visual acuity (BCVA), intraocular pressure (IOP), and central macular thickness (CMT) were collected at the time of FAc administration (baseline) and 1 month, 12 months, and 24 months. The AUC of the BCVA and CMT was correlated with baseline factors.
Results: Fifteen eyes of 10 patients (60 ± 12 years;6 males) were included. BCVA significantly improved from month 6 (p=0.03).The CMT improved from month 1 and was sustainedly lower until month 24 (p<0.001). The AUC of BCVA correlated with baseline BCVA (p<0.001).The AUC of CMT correlated positively with baseline CMT (p=0.02) and negatively with uveitis duration (p=0.04). IOP change follow-up was not significant (p=0.2).
Conclusion: Better visual acuity at the time of FAc administration was associated with better visual outcomes after FAc. Less severe macular edema and longer duration of NIU-PS correlated with better anatomic response.
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability
