Objectives: Nous présentons les résultats d’une étude rétrospective de patients seriés, porteurs de carcinome ou mélanome métastatiques traités par immunothérapie anti-cancéreuse, et présentant une uvéite avec atteinte du segment postérieur ou baisse sévère de l’acuité visuelle. Ces cas ont été éclarés en pharmacovigilance, dans les bases de données nationale et mondiale.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: L’absence d’ostéoblastes, la présence d’un oedème maculaire, la fuite de la fluorescéine en angiographie, et quelques cellules dans le vitré sont des éléments bien connus au cours des dystrophies rétiniennes, qui ont pu être rapportés à une inflammation primitive.
L’échec thérapeutique d’un oedeme maculaire chronique bilateral traité par différents immunosuppresseurs successifs, doit être l’occasion de ré-évaluer vers une cause infectieuse, tumorale ou dystrophique. Reconnaître le phenotype ophtalmologique suggérant une dystrophie rétinienne permet d’effectuer une consultation génétique et une analyse génétique soit par des panels élargis, soit par le séquençage de l’exome ou du génome complet. Certaines présentations cliniques nous permettent de suggérer des gènes candidats.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Les auteurs proposent à travers des cas cliniques de patients présentant un œdème maculaire chronique suite à une rétinite herpétique, récidivant malgré les injections locales de corticoïdes retard.

References : Qian Z, Fardeau C, Cardoso JN, Jellab B, Fan X, LeHoang P. Effect of interferon α2a in cystoid macular edema due to intraocular infection. Eur J Ophthalmol. 2015 Fardeau C, Simon A, Rodde B, Viscogliosi F, Labalette P, Looten V, Tézenas du Montcel S, LeHoang P. Interferon-alpha2a and Systemic Corticosteroid in Monotherapy in Chronic Uveitis: Results of the Randomized Controlled BIRDFERON Study. Am J Ophthalmol. 2017

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Vogt-Koyanagi-Harada (VKH) disease is a bilateral, granulomatous panuveitis typically associated with multiple serous retinal detachments (SRD).[1, 2] The VKH disease presents a roughly good long term out. However the visual prognosis could be threatened by multiple inflammatory recurrences. [3] We discuss the interest of repeated retinal multi-imaging in recurrent VKH posterior uveitis.

Introduction: Recurrent VKH posterior uveitis are reported in 3 cases we women 18, 27, and 43 years old respectively, with typical acute onset of VKH disease. A prompt clinical, biological and radiological work up ruled out others causes of SRD. High doses of corticosteroids were initiated with a quick good response on visual acuity and macular SRD. However, close follow up detected posterior recurrence with VA drop while systemic corticosteroid were slowly tapered.

Materials / method: Repeated retinal multi-imaging showed a persistent pachychoroid in EDI OCT in one patient (case 2), a delayed choroidal filling in ICGA in 2 patients (cases 2 and 3), while in one patient (case 1) persistent peripheral choroidal nodular involvement was only seen in ICGA. Repeated high doses of corticosteroid associated with immunosuppressive drugs in 2 patients, were delivered. At 1 year VA was completely restored in all eyes of the 3patients with no further VKH uveitis recurrences.

Results: : In angiography, choroidal involvement had been showed including hypofluorescent round dots associated with early choroidal stromal vessel hyperfluorescence, resolving on high-dose immunosuppressive therapy; Moreover we showed a delay in choroidal arterial filling that may induce choriocapillaris ischemic lesions and low drug doses delivered in choroidal stroma. Choroidal involvement was found persistent in the current cases even though an initial quick good response to the corticosteroids pulses were seen on VA and retinal thickness.

Conclusion: Retinal blood-flow measured with laser speckle flowgraphy was found significantly lower in recurrent VKH group, This physiopathological statement could explain why the corticosteroid treatment seems to be inefficient for some patients : the reached prednisone concentration in choroidal stroma may be low in the thickened, folded,inflammatory choroid. So while tapering an initial successful treatment of acute VKH, a choroidal imaging checking may be a useful tool in VKH uveitis management to prevent from long term visual function alterations.
Conclusion : Choroidal imaging using both EDI-OCT an

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability